Holmium Laser Resection of the Prostate (HoLRP) Vs Transurethral Resection of the Prostate (TURP): Results of a Randomised Trial with 2 Year Follow-Up
Gilling P, Kennett K, Fraundorfer M

The high-powered Holmium laser has been used commercially since 1994 to incise, ablate, resect, and recently enucleate the adenomatous human prostate. The results of a randomised trial with 2 year follow-up comparing HoLRP and TURP are presented. Of 120 men urodynamically obstructed, 94 men are available for review at 2 years. Each of the patients was followed at 1, 3, 6, 12, 18, and 24 months. Transrectal Ultrasound (TRUS) and urodynamics were performed pre-operatively and at 6 months. At all other time intervals the patients had a peak urinary flow rate (Qmax), American Urological Association (AUA) Symptom Score, continence and potency assessment and a review of adverse events. At 2 years, the mean peak flow rate was 25.1 ml/s in the HoLRP group (n=41) and 19.2 ml/s in the TURP group (n=40), (p=ns). The mean AUA symptom score was 3.4 in the Holmium patients and 2.9 in the TURPpatients (p=ns). There have been 7 strictures in the TURP group, 5 in the HoLRP group, 8 re-operations in the TURP group and 3 in the Holmium group, and one patient in each group requiring pads for stress incontinence. HoLRP and TURP are equivalent at 2 years with fewer adverse events in the Holmium arm to date.

Journal of Endourology, Vol. 13 Supplement 1, A109, Sep 1999

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